CLINICO-HISTOPATHOLOGICAL ANALYSIS OF PRE-MALIGNANT AND MALIGNANT LESIONS OF THE INTESTINAL TRACT

Aim: The current study’s aim is to correlate clinical variables with histopathological findings of pre-malignant and malignant lesions the intestinal tract. Methods: sample size includes all endoscopic biopsies surgically resected specimens tract received at Department Pathology, S.V. Medical College, Tirupathi for 2 years from November 2016 October 2018. All are fixed in 10% formalin stained Hematoxylin Eosin. Special stains Immunohistochemistry were done wherever required. Results: During study, we studied 113 759 resected. Out biopsies, 33 premalignant lesions, among which 8 premalignat 25 malignant. specimens, 37 1 was 36 70 3 occurred small intestine, 59 large anal canal. In encountered which, one each adenoma, PJP, adenocarcinoma noted. intestine 4 adenomas, ulcerative colitis, 48 its variants, MANECs, carcinoid GIST melanoma reported. canal, there mucinous adenocarcinomas, 5 squamous cell carcinomas A case adenoma male patient, adenocarcinomas female patient patient. carcinomas, patients patients. Among adenocarcinoma, out most common symptom bleeding per rectum (63.83%) followed by constipation, pain abdomen diarrhea. association between Adenocarcinoma Smoking not correlated p=0.67. a p=0.38. Conclusion: Most neoplasms neoplasm also malignancy Adenocarcinoma. Different variants study Mucinous Signet ring adenocarcinoma. Adenomas Male Mixed adenoneuroendocrine tumor gastrointestinal stromal confirmed IHC study.